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Preeclampsia prediction study

5 February, 2014

Preeclampsia prediction study

It is hoped that a clinical study that is underway will result in improvments in the prediction of preeclampsia. Posted: 5 February 2014 by Julie Griffiths

Researchers say that there is the possibility of developing a fully automated test to predict preeclampsia.

Blood pressure monitor

Those behind a study, called Prognosis, say that if it yields the anticipated results, then an improved test is likely.

Such a predictive test would enable clinical intervention before the development of full-blown preeclampsia.

More than 1200 people in the UK and 13 countries are enrolled in the study to determine whether a serum test predicts preeclampsia.
 
Researchers are investigating the correlation between the ratio of two proteins sFlt-1 (soluble fms-like tyrosine kinase-1) and PlGF (placental growth factor) in maternal blood and the risk of developing preeclampsia over the subsequent four weeks.

Harald Zeisler, principal investigator for the study, said: 'We hope that early identification of women at high risk of developing preeclampsia will allow healthcare professionals to prevent the most serious effects of the disease and avoid unnecessary expenditure by healthcare systems on excessive medical treatment or unnecessary hospital admission prompted by inadvertently positive diagnoses based on current standard of clinical practice.'

Preeclampsia affects up to 5% of pregnancies in the UK, and severe cases develop in about up to 2% of pregnancies.

Prognosis is a multicentre, prospective, double-blind and non-interventional trial evaluating the short-term prediction of preeclampsia, eclampsia and HELLP (haemolysis, elevated liver enzymes, low platelet count) syndrome in pregnant women with suspected preeclampsia.

The study started enrolling in December 2010 at nine sites in Western Europe and was expanded to 31 sites worldwide across Australia, Canada, New Zealand and Latin America in 2012.


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